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Here we provide evidence that
2023-02-08
Here, we provide evidence that NO contributes to changes in synaptic strength, but also offer an explanation as to why previous attempts to link NO to LTP have often failed. Our results describe a model by which cycling AMPARs, held in intracellular pools, are rapidly delivered to the membrane surfa
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Tissue distribution showed that ctrp was abundantly expresse
2023-02-07
Tissue distribution showed that ctrp9 was abundantly expressed in the kidney of male and female tilapia. In mice, the Ctrp9 was identified in adipose tissue, and the expression levels were higher in females than that of males (Wong et al., 2009). Recent studies indicated that Ctrp9 was also expresse
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It has been reported that HT R involves in type
2023-02-07
It has been reported that 5-HT2R involves in type 2 diabetes mellitus and 5-HT-induced IR [22,23]. The present study also demonstrated that it is 5-HT2R rather than other 5-HT receptors, including 5-HT1BR and 5-HT7R, in the liver that mediates HFD-induced abnormality of hepatic lipid metabolism, and
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Systematic administration of ABT amino bromophenyl
2023-02-07
Systematic administration of ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido[2,3-d] pyrimidine), a potent and selective non-nucleoside AK inhibitor, also generates analgesic effects in animal models of pain (Jarvis et al., 2000, Kowaluk et al., 2000, Suzuki et al., 2001), sug
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Tension within the network could be
2023-02-07
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling make money filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filaments [2
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br Discussion The measurement of gonadotropins FSH LH
2023-02-07
Discussion The measurement of 360A (FSH, LH) is critical in the evaluation and assessment of 46,XX females presenting with primary amenorrhea and lack of pubertal development. A serum level of FSH higher than 40 U/L is diagnostic of ovarian failure (6), as seen in the present case. The most commo
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br Dual role of autophagy in human diseases Emerging evidenc
2023-02-07
Dual role of autophagy in human diseases Emerging evidence suggests that autophagy serves as a double-edged sword in several human diseases, such as CNS diseases (Rubinsztein et al., 2015), arteriosclerosis (Schrijvers et al., 2011) and cancer (Ozpolat and Benbrook, 2015). Likewise, currently the
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Protein phosphorylation is an important posttranslational me
2023-02-07
Protein phosphorylation is an important posttranslational mechanism for the regulation of distribution, trafficking, and function of modified proteins (Wang et al., 2014). GluA1 phosphorylation at S845 also has functional consequences (Lu and Roche, 2012). For instance, S845 phosphorylation drove tr
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The potent inhibition of aromatase by ziram
2023-02-07
The potent inhibition of aromatase by ziram indeed caused the lower estradiol production in JEG-3 cells (Fig. 4), confirming that ziram can penetrate the cell membrane to get into the cells to act. However, the treatment of ziram did not lower progesterone production in JEG-3 cells (Fig. 4), indica
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BMS 470539 dihydrochloride synthesis Coincident with APJ rec
2023-02-07
Coincident with APJ receptor, several cell types in the body can synthesize apelin protein. For example, the highest apelin concentrations in the body have been found in the rat central nervous system, pituitary gland, lungs, cardiac muscle, gastrointestinal tract and mammary glands, with lower valu
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Although the interactions of PhLP with G and its other
2023-02-07
Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls axl inhibitor signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting partn
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MSG model is well characterized and widely used because it
2023-02-07
MSG model is well characterized and widely used because it is not influenced by dietary components and because it mimics a lesion in the arcuate nucleus and lateral hypothalamus that can occur in chronic obese patients (Moraes et al., 2009, Purkayasta and Cai, 2013). High fat fed diet is amongst the
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LP533401 hcl receptor br Introduction Alzheimer s disease AD
2023-02-07
Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different LP533401 hcl receptor areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and K
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Some members from the AAAP family namely the
2023-02-07
Some members from the AAAP family, namely the AUX1 and the LAX proteins, transport auxin instead of amino acids [48]. While there is some structural relationship between IAA and Trp, the substrate recognition characteristics seem different for these proteins: the auxins do not have any amino group o
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In our previous study adiponectin system genes
2023-02-06
In our previous study, adiponectin system (genes and proteins) expression in the porcine endometrium and myometrium was observed on Days 2 to 3, 10 to 12, 14 to 16, and 17 to 19 of the estrous cycle [23]. Adiponectin receptors expression (mRNA) in the porcine endometrium was described by Lord et al.
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