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Compared with qualitative analysis by Kalyankar
2020-01-11
Compared with qualitative analysis by Kalyankar et al. (2013), less sequences were identified in iTRAQ-labelled analysis. It is not surprising with the finding that each of the identified peptide includes the sequence in every sampling point. Glu(51)-Tyr(52) of αs2-casein was observed to have been c
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At present there have been
2020-01-11
At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal tbtu nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relationships is needed, which m
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br Discussion This study characterized
2020-01-10
Discussion This study characterized longitudinal changes of cholinesterase and PON1 enzyme activities in greenhouse workers over two periods of a crop season with different levels of pesticide exposure. Although study participants were not exposed to OP insecticides, because they worked under int
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EphB promotes tumor growth by stimulating
2020-01-10
EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of 20 hydroxyecdysone and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood
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Introduction Ubiquitylation is a post translational modifica
2020-01-10
Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti
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Currently much effort has been made to design
2020-01-10
Currently, much effort has been made to design and synthesize ThDP analogs (such as ThTDP, ThTTDP, and triazole-ThDP in Fig. 2)8, 9, 10, 11, 12 as PDHc E1 inhibitors. These ThDP analog inhibitors, such as ThTDP and ThTTDP, can block the ThDP binding site, and exhibit significantly stronger binding a
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br Materials and methods br
2020-01-10
Materials and methods Results Discussion Adiponectin is one of the most studied adipocytokines. Its release from adipocytes is down-regulated in obesity and other adverse metabolic conditions leading to decreased serum concentrations (Turer and Scherer, 2012). Several factors and conditions
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br Benefits and risks of traditional
2020-01-10
Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related
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br Acknowledgements This work was financially supported
2020-01-10
Acknowledgements This work was financially supported by Industrial Technology Institute, Sri Lanka through funds received from Sri Lankan Government Treasury (TG13/69). G. D. Liyanaarachchi received postgraduate research scholarship grant from National Science Foundation Sri Lanka (NSF/SCH/2017/0
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Many PIM inhibitors have been reported to date however
2020-01-09
Many PIM inhibitors have been reported to date [7], [8], [9] however, none of them has been marketed so far. SGI-1776 is a representative first-generation PIM inhibitor, which had been under clinical trials for leukemia and prostate cancer [10]. While most of the first-generation PIM inhibitors are
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It has previously been shown
2020-01-09
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Tubastatin A on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that t
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br Introduction Acinetobacter baumannii is a gram
2020-01-09
Introduction Acinetobacter baumannii is a gram-negative opportunistic pathogen that causes nosocomial infections including pneumonia and bloodstream infections which is associated with an increased mortality and multi-drug resistance [[1], [2], [3]]. A. baumannii was rated as one of the critical
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br Introduction The offspring of rodents emit vocalizations
2020-01-09
Introduction The offspring of rodents emit vocalizations when isolated from their dam. The majority of vocalizations by rat pups are in the ultrasonic band frequency of 30–50 kHz (Insel et al., 1986). Maternal separation-induced ultrasonic vocalizations are believed to represent distress signals
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br Acknowledgements This work was supported by the
2020-01-09
Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360. We are grateful to Dr. T.T. Hoang for the provision of plasmids pEX18Tc, pPS858 and pFLP2, Prof. B.L. Wanner for providing us with the plasmid pKD4 and related strains, and Prof. P. Soucail
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Structural homology modelling Intensive Phyre modelling was
2020-01-09
Structural homology modelling. Intensive Phyre2 modelling [44] was performed using the primary amino Betamethasone Dipropionate sequence of A1S_0222 as input to generate an atomistic 3D-homology model of A1S_0222. The fit to the SAXS data of the homology model as well as the fit to the data of the
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