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La no intervenci n en los
2019-06-10
La no intervención en los asuntos de otro Estado no significa indiferencia ante los problemas que éste pueda tener. En efecto, algunos usos y gestiones pueden perjudicar bet inhibitor países vecinos y también al mismo Estado que las realiza. Es por esto que la soberanía no resulta absoluta en lo que
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En una clara cr tica
2019-06-10
En una clara crítica al modelo neoliberal gay importado de Estados Unidos, Néstor Perlongher sostiene que “el gay pasa orthopoxvirus variola tomarse como modelo de conducta. Este operativo de normalización arroja a los bordes a los nuevos marginados, los excluidos de la fiesta: travestis, locas, cho
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br Disclosures br Acknowledgments This study was supported b
2019-06-10
Disclosures Acknowledgments This study was supported by the Austrian National Science Fund (FWF), Grant # SFB-F4704. Introduction Acute lymphoblastic leukemia (ALL) is the most frequent childhood malignancy. Extramedullary involvement of the kidneys is seen in around 7% when assessed by in
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br Discussion Chronic myelogenous leukemia
2019-06-10
Discussion Chronic myelogenous leukemia (CML) is a clonal disorder involving the pluripotent stem cell and is consistently associated with the BCR-ABL1 fusion gene located on the Philadelphia chromosome [1]. The disease typically evolves in 3 distinct clinical stages: chronic and accelerated phas
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solution calculator For example glutamate is increasingly re
2019-06-10
For example, glutamate is increasingly recognized as one of the important dysregulated signaling molecules in cancer biology, especially in the context of bone metastasis. Commonly recognized as an excitatory neurotransmitter necessary for normal solution calculator function, glutamate is also inti
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The presence of an inflammatory infiltrate is associated
2019-06-10
The presence of an inflammatory infiltrate is associated with poor prognosis in a number of malignancies, including those with a predilection for metastasis to bone. CAFs are capable of promoting, and maintaining an inflammatory environment by recruiting immune cells; in particular monocyte/macropha
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The authors of the NCCN
2019-06-10
The authors of the NCCN non-small cell lung cancer guidelines provide the most guidance about radiotherapy dosing for painful bone metastases of any of the primary sites evaluated [39]. Bone metastases due to non-small cell lung cancer are separated into those “with soft tissue mass” versus those “w
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EVP-6124 Roughly years have gone by since the identification
2019-06-10
Roughly 15 years have gone by since the identification of the main characters involved in the interplay of the RANK–RANKL system. This gave rise to the race for elucidating their biological role . In those years, in vivo silencing experiments for both Receptor Activator of Nuclear Factor κ B (RANK)
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X rays commonly show a
2019-06-10
X-rays commonly show a typical licked candy stick appearance, based on concentric bone resorption. Common blood tests are usually normal, but bone alkaline phosphatase (BAP) may be elevated if a fracture occurred [8]. GSD is a diagnosis of exclusion. Diseases responsible of bone osteolysis such as i
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Cisplatin based chemotherapy is commonly used
2019-06-06
Cisplatin-based chemotherapy is commonly used in adjuvant CCRT, but data on carboplatin-based chemotherapy with radiotherapy is lacking. Khoury et al reported that patients treated with carboplatin-based chemoradiotherapy show worse outcomes. However, the impact on patient comorbidities was not repo
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br Sebastian Vollmer and colleagues April conclude that the
2019-06-06
Sebastian Vollmer and colleagues (April, 2014) conclude that “the contribution of economic growth to the Senexin B in early childhood undernutrition in developing countries is very small, if it exists at all”. Progress will therefore require a shift from “the so-called trickle-down approach of a
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In patients with typical atrial
2019-06-06
In patients with typical atrial flutter circulating around the tricuspid valve, the verification of a bidirectional conduction block is recommended for cavotricuspid isthmus (CTI) ablation, because a unidirectional conduction block at the CTI has been previously reported to cause recurrence of atria
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Introduction Atrial fibrillation AF is a common cardiac arrh
2019-06-06
Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia that becomes more prevalent with age [1] and is associated with an increased long-term risk of stroke, order Rupatadine Fumarate failure, and all-cause mortality [2]. Since Einthoven recorded the electrograms in 1906 [3], AF has
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Primarily the management of GCTs has been curettage followed
2019-06-06
Primarily, the management of GCTs has been curettage followed by filling with bone cement [7,19]. However this has been associated with high recurrence rates. Additional treatment with adjuvants is often employed to reduce this recurrence. These adjuvants may include zinc chloride, bisphosphonates,
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In addition our present findings demonstrated that NOACs may
2019-06-06
In addition, our present findings demonstrated that NOACs may offer advantages over warfarin therapy besides efficiency and safety. The time to ECV in the present OAC-naïve patients was significantly shorter in the NOAC group compared to the VKA group. This may be explained by the delayed achievemen
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